logo Research, Innovation and Dissemination Centers

Center for Research and Innovation in Biodiversity and Drug Discovery

CEPID 2001-2013
CEPID 2013-2024
Website: http://cibfar.ifsc.usp.br

Principal investigator: Glaucius Oliva 
Education and knowledge diffusion coordinator: Leila Maria Beltramini 
Technology transfer coordinator: Adriano Defini Andricopulo 

University of São Paulo (USP)
Instituto de Física de São Carlos
Av. João Dagnone, 1.100
13563-120 - São Carlos, SP - Brasil

Federal University of São Carlos (UFSCar)
São Paulo State University (UNESP)
State University of Campinas (UNICAMP)

BV-FAPESP: research projects supported in this Center 

CIBFar in the Media: news about the Center


The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) has the main goal of performing basic and applied science, as well as technological development in all the areas of biodiversity and drugs discovery on the basis of research that uses the state of the art of chemistry of natural products, synthetic organic chemistry, molecular and structural biology, biochemist, medicinal chemistry, drug design and pharmacological assays.

The specific objectives are the bioprospecting of  Brazilian flora to identify the components with an ample specter of biological activities (e.g., antiparasitic, antibacterial, anticancer); selection of promising bioactive compounds for organic synthesis, and studies of the relations between the structure and activity (SAR, QSAR); use of strategies of drug design based in the structure of the receiver (SBDD) and the binder (LBDD); use approaches for optimizing compounds-leaders; preclinical efficacy studies, toxicology and pharmacokinetics in vitro and in vivo for the evaluation and optimizing of properties of new drug candidates.

The ultimate goal is the development of new chemical entities (NCEs) with the raised potential of innovation for clinical development. Therefore, the CIBFar is not only based on the abilities and solid scientific knowledge in all the interest areas, but also in an organized structure for the integration of modern approaches in biodiversity and drugs discovery.

CIBfar main characteristic is the well-established infrastructure in terms of skills for technical, financial, technological education, and executive management. Maximum integration with the productive sector will be held to identify opportunities and the definition of goals. In the educational aspect, the Center counts on the significant experience acquired throughout one decade in education and dissemination of the knowledge carried through in the CEPID-FAPESP.

CIBFar is a joint initiative resulting from collaborative research projects, including the: (i) Medicinal and Computational Chemistry Laboratory (LQMC) and Laboratory of Molecular Biophysics – São Carlos Institute of Physics at the University of São Paulo – IFSC/USP; (ii) Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NUBBE) – Institute of Chemistry at the State University of São Paulo IQ/UNESP; (iii) Organic Synthesis Laboratories – Institute of Chemistry at the State University of Campinas – IQ/UNICAMP; (iv) Laboratories of Natural Products and Organic Synthesis – Department of Chemistry at the Federal University of São Carlos – DQ/UFSCar; and (v) Natural Products Laboratory – School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo – FCFRP/USP.