The Redox Processes in Biomedicine RIDC (Redoxoma) is a multidisciplinary network of investigators focused on a concerted approach to investigating redox processes. These processes involve electron transfer reactions via free radicals or non-radical intermediates, and have a unique potential to elucidate biochemical pathways underlying cell and organ (patho) physiology, as well as to disclose disease mechanisms and therapeutic targets. This enormous potential has not yet been fulfilled, mainly because of insufficient basic mechanistic knowledge.
The Redoxome Center investigates issues relevant to overcoming such limitations to allow the design of effective antioxidant strategies and biomarkers of oxidative stress. Specifically: 1) oxidants and radical generation and control in biological systems; 2) chemical reactivity of oxidants and radicals in biological environments and consequent changes in the structure and function of biomolecules; 3) mechanisms and networks involved in redox signaling processes relevant to human disease; 4) diagnostic and therapeutic applications of redox processes. Such investigations comprise a coherent set of interconnected studies expected to bridge meaningful conceptual gaps in the field and to allow technological and educational advances.
The pervasiveness of redox processes in the environment opens many possibilities for technological applications. Several public and private industrial sectors will benefit from new technologies developed by the Redoxome Center, varying from those in which Brazil has already acquired international leadership (personal care, fragrances, cosmetics, bioenergy) to those in which industries are emerging but are still not competitive in the national and international markets (pharmaceutical, medical devices, diagnostics, ecological services). The main goal is to innovate in these industrial sectors. In addition, the aim is to implement a core laboratory (Redoxoma Analysis Platform – RAP) at USP to provide state-of-the-art analytical tools for the evaluation of redox processes, which will be open for use by clinical and basic researchers. Redox state markers should favor early detection of risk factors for a number of diseases, allowing the design of adequate interventions and maximizing the chances of correcting these conditions.
In terms of education and knowledge diffusion, the Redoxome center will target students from all levels (primary education, high school, undergraduates, graduate), teachers and the general public. The actions are structured around four main axes: 1) courses: development of courses for graduate and undergraduate students, and for teachers continuing their professional development; 2) didactic resources: development of curriculum materials to complement science classes and experimental activities at a website; 3) scientific diffusion: a permanent exhibition at a science museum and the development of a website; and 4) educational projects: scientific research initiation at high school level supervised by teachers. In addition, the entire context of this plan and the actions derived from it will be used as research material for academic research in Science Education.
Researchers at the University of São Paulo observed the effects of adiponectin in trials involving blood samples from lean and obese subjects. The discovery points to novel routes to treatment for type 2 diabetes and related dysfunctions.
An article in Cell by researchers affiliated with Harvard and the University of São Paulo shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
Adaptation of muscle tissue to aerobic exercise alters the metabolism of muscle stem cells, helping them recover from injury. Findings may contribute to treatment of cachexia, sarcopenia and other conditions associated with lean mass loss.