logo Research, Innovation and Dissemination Centers

Center for Research on Redox Processes in Biomedicine

CEPID 2013-2024

Site: http://redoxoma.iq.usp.br

Principal investigator: Ohara Augusto 
Education and knowledge diffusion coordinator: Carmen Fernandez 
Technology transfer coordinator: Paolo Di Mascio

University of São Paulo (USP)
Av. Prof. Lineu Prestes, 748
Cidade Universitária
05508-000 - São Paulo, SP - Brasil

Aarhus University, Denmark
AC Camargo Cancer Center
Atomic Energy and Alternative Energies Commission (CEA), France
Boston University, USA
Butantan Institute (IBu)
Centre National de la Recherche Scientifique (CNRS), France
Emory University, USA
Federal University of São Paulo (UNIFESP)
Harvard University, USA
Heart Institute (INCOR/USP)
Koç University, Turkey
Liverpool John Moores University, United Kingdom
National Institute on Aging (NIA), USA
São Paulo State University (UNESP)
University of Madrid, Spain
University of Milwaukee, USA
University of Rochester, USA
University of the Republic, Uruguai

BV-FAPESP: research projects supported in this Center 

Redoxoma in the Media: news about the Center


The Redox Processes in Biomedicine RIDC (Redoxoma) is a multidisciplinary network of investigators focused on a concerted approach to investigating redox processes. These processes involve electron transfer reactions via free radicals or non-radical intermediates, and have a unique potential to elucidate biochemical pathways underlying cell and organ (patho) physiology, as well as to disclose disease mechanisms and therapeutic targets. This enormous potential has not yet been fulfilled, mainly because of insufficient basic mechanistic knowledge.

The Redoxome Center investigates issues relevant to overcoming such limitations to allow the design of effective antioxidant strategies and biomarkers of oxidative stress. Specifically: 1) oxidants and radical generation and control in biological systems; 2) chemical reactivity of oxidants and radicals in biological environments and consequent changes in the structure and function of biomolecules; 3) mechanisms and networks involved in redox signaling processes relevant to human disease; 4) diagnostic and therapeutic applications of redox processes. Such investigations comprise a coherent set of interconnected studies expected to bridge meaningful conceptual gaps in the field and to allow technological and educational advances.

The pervasiveness of redox processes in the environment opens many possibilities for technological applications. Several public and private industrial sectors will benefit from new technologies developed by the Redoxome Center, varying from those in which Brazil has already acquired international leadership (personal care, fragrances, cosmetics, bioenergy) to those in which industries are emerging but are still not competitive in the national and international markets (pharmaceutical, medical devices, diagnostics, ecological services). The main goal is to innovate in these industrial sectors. In addition, the aim is to implement a core laboratory (Redoxoma Analysis Platform – RAP) at USP to provide state-of-the-art analytical tools for the evaluation of redox processes, which will be open for use by clinical and basic researchers. Redox state markers should favor early detection of risk factors for a number of diseases, allowing the design of adequate interventions and maximizing the chances of correcting these conditions.

In terms of education and knowledge diffusion, the Redoxome center will target students from all levels (primary education, high school, undergraduates, graduate), teachers and the general public. The actions are structured around four main axes: 1) courses: development of courses for graduate and undergraduate students, and for teachers continuing their professional development; 2) didactic resources: development of curriculum materials to complement science classes and experimental activities at a website; 3) scientific diffusion: a permanent exhibition at a science museum and the development of a website; and 4) educational projects: scientific research initiation at high school level supervised by teachers. In addition, the entire context of this plan and the actions derived from it will be used as research material for academic research in Science Education.